Thinking Fast and Slow

The research found that angiotensin‐converting enzyme 2 (ACE2) was the receptor for SARS‐CoV‐2. In the normal human lung, ACE2 is expressed on type I and II alveolar epithelial cells. Among them, 83% of the type II alveolar cells have ACE2 expression. Men had a higher ACE2 level in their alveolar cells than women. Asians have a higher level of ACE2 expression in their alveolar cells than the White and African American populations. The binding of SARS‐CoV‐2 on ACE2 causes an elevated expression of ACE2, which can lead to damages on alveolar cells. Damages to alveolar cells can, in turn, trigger a series of systemic reactions and even death. The research also confirmed that Asian males are more susceptible to SARS‐CoV‐2 infection. The receptor‐binding ability of SARS‐CoV‐2 is 10 to 20 times stronger than that of SARS‐CoV. Scientists found that 98% of the patients in their study had fevers, of which 78% had a temperature higher than 38°C. They reported that 76% of the patients had coughs,...

COVID-19 AND DIABETES As we all know how drastic effect has been caused by the novel coronavirus Today we are going to discuss about the about the COVID with the diabetes  the various factors such as follows:- Higher Risk? Symptoms? Extra Precautions? Dietary Changes? Go out for walk? Grocery Shopping? I hope by the end of this article you will come away with more information and practical knowledge Are diabetics more prone to COVID-19? In the present situation there no such clinical data which suggest higher risk of acquiring the disease obviously if there are elderly people who have got uncontrolled diabetes or other commodities the risk may be higher but otherwise in vast majority of stable young population with diabetes is unlikely to be at higher risk however its very pertinent  to point out that if a person with diabetes specially with those with uncontrolled sugar does acquire the disease, the course of the disease in them tends to be more ...

PROCHLORPERAZINE Prochlorperazine (PCZ) inhibits the internalization of receptors on the surface of the tumor cells, thereby increasing the ability of the anticancer antibodies to bind to the receptors and mount more effective immune responses. PCZ enhanced the ability of anticancer antibodies to reduce tumor growth in mice, by temporarily increasing the clustering of a receptor targeted by anticancer antibodies on the surface of tumor cells. Temporary treatment of cancer patients with PCZ similarly resulted in receptor clustering on tumor cells inside of patients. In addition to treating nausea and psychosis, PCZ is currently used in laboratory as inhibitor of endocytosis. The temporary inhibition of endocytosis via molecules such as PCZ has been proposed for numerous clinical applications, including control of viral infection, epilepsy and chronic kidney disease. When tumor samples from patients were analyzed with sqaumous cell carcinoma, they found that decrease in endocytosi...

World Cancer Day (4 Feb) World Cancer Day, organized by the Union for International Cancer Control (UICC) and celebrated each year on 4 February, is an opportunity to rally the international community to end the injustice of preventable suffering from cancer. As per WHO ( world health organization), This year theme, "I can, we can" acknowledges that everyone has the capacity to address the cancer burden. We can work together to reduce cancer risk factors. We can overcome barriers to early diagnosis, treatment and palliative care. We can work together to improve cancer control and achieve global targets to reduce premature mortality from cancer and NCDs. Cancer Prevention  Between 30-50% of all cancer cases are preventable. Prevention offers the most cost effective long term strategy for the control of cancer. National policies and programmes should be implemented to raise awareness, to reduce exposure to cancer risk factors and to ensure that people are provided...

The world health organization (WHO) says, 'Not enough is known about 2019 Novel coronavirus (2019-nCoV) to draw definitive conclusions about how it transmitted, clinical features of disease, or the extent to which it has spread. The source also remains unknown' The following information is based upon interim draft guidelines and is subject to change as and when newer recent information is received. According to WHO, a new type of coronavirus (2019 novel coronavirus, nCoV) has been identified in China on 7 January 2020. The cluster of patients with pneumonia-like-illness was initially reported on 31 December 2019. What is the nCoV? Coronavirus are the family of  respiratory viruses, named for the crown- like spikes on the surface. Coronaviruses can cause diseases ranging from the common cold to Middle-East Respiratory Syndrome and Severe Acute Respiratory Syndrome (SARS). The Novel coronavirus, nCoV is a new strain of coronavirus that has not been previously iden...

The mechanism behind how HIV can develop resistance to a widely prescribed group of drugs has been uncovered by new research, with the findings opening the door to the development of more effective treatments. Today a number of drugs are available which help to control HIV infection, including a group called integrase strand transfer inhibitors. There are four drugs within this family of medication: raltegravir , elvitegravir , dolutegravir , bictegravir . They all work by binding with one of HIV's key enzymes, called integrase, to stop it from inserting the virus genetic information into DNA of human cells. While initially highly effective, over time HIV can develop resistance to these drugs. The study discovered the mechanism HIV uses to develop resistance to this group of drugs. Although the drugs are normally very effective at binding and blocking integrase, over time, the virus can weaken this bond and thus enable its key enzyme to work again. The researchers uncovered ...