THE DANGER OF NOVEL CORONAVIRUS

-
The world health organization (WHO) says, 'Not enough is known about 2019 Novel coronavirus (2019-nCoV) to draw definitive conclusions about how it transmitted, clinical features of disease, or the extent to which it has spread. The source also remains unknown'
The following information is based upon interim draft guidelines and is subject to change as and when newer recent information is received.
According to WHO, a new type of coronavirus (2019 novel coronavirus, nCoV) has been identified in China on 7 January 2020. The cluster of patients with pneumonia-like-illness was initially reported on 31 December 2019.

What is the nCoV?

Coronavirus are the family of  respiratory viruses, named for the crown- like spikes on the surface. Coronaviruses can cause diseases ranging from the common cold to Middle-East Respiratory Syndrome and Severe Acute Respiratory Syndrome (SARS). The Novel coronavirus, nCoV is a new strain of coronavirus that has not been previously identified in humans. They are notorious for mutating quickly and acquiring new qualities.

What are the Symptoms and Signs of infection with Novel coronavirus, nCoV?

The symptoms reported are mainly fever, with a few having difficulty in breathing Chest Xrays are showing invasive pneumonic infiltrates in both lungs.This can be differentiated from other respiratory infections excepting a history of travel to affected geographical area.

What is the course of Illness?

As of now more than 41 cases with the novel coronavirus infection have been preliminarily diagnosed in Wuhan City of China. Of the 41 cases two deaths have been reported and at least one of the patient had other underlying health conditions. While seven severely ill, six patients have been discharge from  hospital. The risk of cases being reported from elsewhere is increased, especially considering heavy population movements during the Chinese New Year in the last week of January.

How is the infection transmitted?

The transmission potential and modes of transmission as of now remain largely unclear.
The evidence is highly suggestive that the outbreak is associated with the exposures in one seafood market in Wuhan. Most of the cases affected worked at or were handlers and frequent visitors to the Human Seafood Wholesale Market. Preliminary epidemiology also suggests an animal source and thus a zoonotic disease. At this stage, there is no clear evidence but high suspicion of limited human transmission of infection. No case has been reported as yet among health care workers.

What are the criteria for evaluation of Patients Under Investigation (PUI) for 2019-nCoV (source- CDC 2020)?

  • Fever and symptoms of lower respiratory illness (eg., cough difficulty breathing) and in the last 14 days before symptom onset, a history of travel from Wuhan City, China.
  • In the last 14 days before symptom onset, close contact with a person who is under investigation for 2019-nCoV while that person was ill.
  • Fever or symptoms of lower respiratory illness (eg., cough, difficulty breathing) and in the last 14 days, close contact with an ill laboratory-confirmed 2019-nCoV patient.

Fever may not be present in some patients, such as those who are young, elderly, immunosuppressed, or taking certain fever lowering medications. Clinical judgment should be used to guide testing of patients in such situations.
Close contact is defined as-
  • Being within approximately 6 feet (2 meters), or within the room of care area, of a novel coronovirus case for a prolonged period of time while not wearing appropriate personal protective equipment (eg., gowns, gloves, N95 respirator, eye protection). Close contact can include caring for, living with, visiting, or sharing a health care waiting area or room with a novel coronavirus case or
  • Having direct contact with the infectious secretions of a novel coronavirus case (eg., being coughed on) while not wearing appropriate personal protective equipment.

Travel Advisory

General preventive measures to be practiced while travelling in or from China:

  • Observe good personal hygiene
  • Namaste works best to avoid hand contact
  • Practice frequent hand washing with soap
  • Follow respiratory etiquette. The components of respiratory Hygiene/Cough Etiquette are:
Practice frequent hand-hygiene at all times
Keep at arm's length / Maintain a distance of minimum 3 feet from a person who is sneezing or coughing.
Whenever possible, use disposable tissues to cover your cough and cold 
Discard the used tissues immediately into an appropriate waste bin and practice hand hygiene
Offer a surgical mask to person who is coughing or sneezing
  • Avoid close contact with the people who are unwell or showing symptoms of illness, such as cough, runny nose etc
  • Avoid contact with the live animals and consumption of raw/uncooked meats
  • Avoid travel to farms, live animal markets or where animals are slaughtered
  • Wear a mask if you have respiratory symptoms such as cough or runny nose

All travelers to China (in particular Wuhan city) to monitor their health closely

If you feel sick and have fever and cough:
  • cover your mouth while coughing or sneezing
  • Don't plan travels if sick
  • Seek medical attention promptly
If you feel sick on the flight, while travelling back  to India:
  • Inform the airlines crew about illness
  • Seek mask from the airlines crew.
  • Avoid close contact with family members or fellow travelers
  • Follow the direction of the airline crew while disembarking
If you feel sick on flight or at the time of disembarking:
  • Report to airport health authorities/immigrations
  • Special counters are being opened in Delhi, Kolkata and Mumbai airports
  • Follow the direction of the airport health officer
If you feel sick with a span of one month after return from China:
  • Report the illness to the nearest health facility and also inform the treating doctor regarding your travel history 

Treatment

There is no specific treatment for disease caused by the novel coronavirus. Treatment is mainly symptomatic and supportive, based on the patients clinical condition. As of now, there is no vaccine available.

Precautions for the household members to patients with suspected/ confirmed patients with 2019-nCoV Infection/ Respiratory Symptoms

  • Wash your hands often and thoroughly with the soap and water f\or at least 20 seconds.
  • Use an alcohol- based hand sanitizer if soap and water are not available and if your hands are not visibly dirty.
  • Avoid touching your eyes, nose, and mouth with unwashed hands.
  • For providing care at home, have only the essential people in the home. Other household members should stay in another home, if possible/ another room/ be separated from the person as much as possible.
  • Use a separate bathroom, If available.
  • Restrict visitors who do not have essential need to be in the home.
  • Keep elderly people / those who have compromised immune systems/ chronic health conditions- heart, ling or kidney conditions, and diabetes away from the person.
  • Keep a window open or let the air conditioner be on.
  • Wear a disposable face mask, gown, when you touch or have contact with the person's blood, body fluids and/ or secretions- swear saliva, sputum, nasal mucus, vomit, urine, or diarrhea and gloves when required.
  • Discard used face masks, gowns, and gloves after use and Wash hands immediately.
  • Do not share towels, eating utensils dishes, drinking glasses, cups, bedding, or other items with the suspected patient.
  • Wash thoroughly with soap and water after use.
  • Clean all "high touch" surfaces, such as counters, tabletops, doorknobs, bathroom fixtures, toilets, phones, keyboards, tablets, and beside tables every day.
  • Also, clean any surfaces that may have blood, body fluids and/or secretions or excretions on them. 
  • Monitor your health starting from the day you first had close contact with the person and continue for 14 days after you last had close contact with the person. Take your temperature twice a day. Be alert to coughing, Shortness of breath, chills, body aches, sore throat, headache, diarrhea, nausea/vomiting and runny nose.
There is NO REASON TO PANIC. Please follow Indian National guidelines from NCDC or MOHFW, Govt. of India and state of Government guidelines as and when they are available. Hand hygiene and respiratory etiquette seem to be the containment strategy as of now.

References

  • CDC https://www.cdc.gov/ncird/index.html2020
  • MOHFW, Govt. of India Novel Corona Outbreak in China- Travel advisory for travelers visiting China https://mohfw.gov.in/media/disease-alerts 

Comments

Post a Comment

Popular posts from this blog

Carbonic anhydrase inhibitors (Acetazolamide)

-
Image
Carbonic anhydrase inhibitors Overview: Acetazolamide, the prototype Carbonic Anhydrase Inhibitors, inhibits carbonic anhydrase and in doing so reduces renal bicarbonate resorption in the proximal tubule. This leads to a direct increase in urinary bicarbonate excretion and secondarily to mild increases in sodium and potassium excretion. Because of its mild effects on electrolytes acetazolamide is a largely safe drug with few adverse side effects but in consequence is rarely used for its diuretic capacity. Mechanism of action: Effects on Bicarbonate:  The pharmacological effects of acetazolamide are due to its inhibitory effect on carbonic anhydrase in the proximal tubule. As discussed in R enal Bicarbonate Excretion , luminal and intracellular pools of carbonic anhydrase in the proximal tubule are critical for resorbing filtered bicarbonate and thus administration of acetazolamide results in significant increases in renal bicarbonate excretion. Because bicarbonate acts a
Read more

THE IMMUNE SYSTEM NEW DEVELOPMENTS IN RESEARCH PART 1

-
Image
INTRODUCTION TO IMMUNOLOGY Hello, I am Gajendra Choudhary , welcome to my new blog, The Immune System, New Developments in Research. Do you know how your own body protects you from viruses and other pathogens? Would you be surprised to hear that cancer may also be controlled by your immunity? Every day immunology research aims to understand the mysteries of our bodies and seeks out the seeds for medical application. This course introduces wide ranging content in general immunology fields from basic knowledge to front line research. In particular, I hope that from this course you gain necessary understanding of the new world of immunology, the world opened up by the illustrious immunologists of the past, and the unexplored mysteries that are yet to be explained by experiencing a part of the front line research currently in progress. In this series, we will be learning how the immune system works, in particular how the components of the immune system interact with each other, and
Read more

GLYCOLYSIS

-
Image
GLYCOLYSIS The official spokesperson of carbohydrate metabolism ,'glucose', speaks: "I burn myself to provide fuel to life! Generated through gluconeogenesis by my friends; Engaged in the synthesis of lipids, amini acids; Deranged in my duties due to diabetes melitus." INTRODUCTION Glycolysis is derived from the Greek words (g;lycose- sweet or sugar; lysis -dissolution). Universal pathway in the living cells. This pathway is often referred to as Embden Meyerhof pathway (E.M. pathway). Definition:  Glycolysis is defined as the sequence of reactions converting glucose(or glycogen) to pyruvate or lactate, with the production of ATP. what i am gonna do now is try to make it more interesting for you guys to understand this topic.. it will be a brief conversation between 2 people so lets see how it goes. Fun way to understand glycolysis The conversation between two people to make you guys understand glycolysis more efficiently.
Read more